Journal
FRONTIERS IN MOLECULAR NEUROSCIENCE
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnmol.2019.00313
Keywords
diffusion-trapping; inhibitory synapse; GABA(A) receptor; glycine receptor; gephyrin; single-particle tracking
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Funding
- Fondation pour la Recherche Medicale (FRM) postdoctoral fellowship [SPF201809007132]
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The dynamic modulation of receptor diffusion-trapping at inhibitory synapses is crucial to synaptic transmission, stability, and plasticity. In this review article, we will outline the progression of understanding of receptor diffusion dynamics at the plasma membrane. We will discuss how regulation of reversible trapping of receptor-scaffold interactions in combination with theoretical modeling approaches can be used to quantify these chemical interactions at the postsynapse of living cells.
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