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Erythropoietin treatment leads to reduced blood glucose levels and body mass: insights from murine models
Odelia Katz et al.
JOURNAL OF ENDOCRINOLOGY (2010)
Mammalian target of rapamycin Hitting the bull's-eye for neurological disorders
Zhao Zhong Chong et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2010)
ERK- and Akt-Dependent Neuroprotection by Erythropoietin (EPO) against Glyoxal-AGEs via Modulation of Bcl-xL, Bax, and BAD
Jianfeng Shen et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2010)
DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival
Timothy R. Peterson et al.
CELL (2009)
Downregulation of cell survival signalling pathways and increased cell damage in hydrogen peroxide-treated human renal proximal tubular cells by alpha-erythropoietin
M. Andreucci et al.
CELL PROLIFERATION (2009)
FoxO proteins: cunning concepts and considerations for the cardiovascular system
Kenneth Maiese et al.
CLINICAL SCIENCE (2009)
Upregulation of the Mammalian Target of Rapamycin Complex 1 Pathway by Ras Homolog Enriched in Brain in Pancreatic β-Cells Leads to Increased β-Cell Mass and Prevention of Hyperglycemia
Suirin Hamada et al.
DIABETES (2009)
Specific Activation of mTORC1 by Rheb G-protein in Vitro Involves Enhanced Recruitment of Its Substrate Protein
Tatsuhiro Sato et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Mammalian Target of Rapamycin Complex 1 (mTORC1) Activity Is Associated with Phosphorylation of Raptor by mTOR
Lifu Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Efficacy of combined inhibition of mTOR and ERK/MAPK pathways in treating a tuberous sclerosis complex cell model
Ruifang Mi et al.
JOURNAL OF GENETICS AND GENOMICS (2009)
Short-Term Calorie Restriction in Male Mice Feminizes Gene Expression and Alters Key Regulators of Conserved Aging Regulatory Pathways
Preston Wayne Estep et al.
PLOS ONE (2009)
Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1
Yasukazu Nakahata et al.
SCIENCE (2009)
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
Juan M. Garcia-Martinez et al.
BIOCHEMICAL JOURNAL (2008)
Triple play: Promoting neurovascular longevity with nicotinamide, WNT, and erythropoietin in diabetes mellitus
Kenneth Maiese
BIOMEDICINE & PHARMACOTHERAPY (2008)
SIRT1 regulates circadian clock gene expression through PER2 deacetylation
Gad Asher et al.
CELL (2008)
Erythropoietin and oxidative stress
Kenneth Maiese et al.
CURRENT NEUROVASCULAR RESEARCH (2008)
Raves and risks for erythropoietin
Kenneth Maiese et al.
CYTOKINE & GROWTH FACTOR REVIEWS (2008)
mTOR inhibition by rapamycin prevents β-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes
Merav Fraenkel et al.
DIABETES (2008)
Life span extension and neuronal cell protection by Drosophila nicotinamidase
Vitaly Balan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
The Wnt signaling pathway: Aging gracefully as a protectionist?
Kenneth Maiese et al.
PHARMACOLOGY & THERAPEUTICS (2008)
The genetics of very early onset Alzheimer disease
Christopher M. Filley et al.
COGNITIVE AND BEHAVIORAL NEUROLOGY (2007)
PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex
Bruno D. Fonseca et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Antioxidant effect of erythropoietin on 1-methyl-4-phenylpyridinium-induced neurotoxicity in PC12 cells
Yan Wu et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2007)
Erythropoietin involves the phosphatidylinositol 3-kinase pathway, 14-3-3 protein and FOXO3a nuclear trafficking to preserve endothelial cell integrity
Z. Z. Chong et al.
BRITISH JOURNAL OF PHARMACOLOGY (2007)
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCα but not S6K1
David A. Guertin et al.
DEVELOPMENTAL CELL (2006)
Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: Possible involvement in obesity-linked insulin resistance
L Khamzina et al.
ENDOCRINOLOGY (2005)
Oxidative stress in the brain: Novel cellular targets that govern survival during neurodegenerative disease
ZZ Chong et al.
PROGRESS IN NEUROBIOLOGY (2005)
New avenues of exploration for erythropoietin
K Maiese et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2005)
Erythropoietin in the brain: can the promise to protect be fulfilled?
K Maiese et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2004)
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
E Jacinto et al.
NATURE CELL BIOLOGY (2004)
TSC2 mediates cellular energy response to control cell growth and survival
K Inoki et al.
CELL (2003)
GβL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
DH Kim et al.
MOLECULAR CELL (2003)
Erythropoietin fosters both intrinsic and extrinsic neuronal protection through modulation of microglia, Akt1, Bad, and caspase-mediated pathways
ZZ Chong et al.
BRITISH JOURNAL OF PHARMACOLOGY (2003)
Apaf-1, Bcl-xL, cytochrome c, and caspase-9 form the critical elements for cerebral vascular protection by erythropoietin
ZZ Chong et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2003)
Erythropoietin prevents early and late neuronal demise through modulation of Akt1 and induction of caspase 1, 3, and 8
ZZ Chong et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2003)
Identification of differentially expressed mRNA during pancreas regeneration of rat by mRNA differential display
HW Lim et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteases
ZZ Chong et al.
CIRCULATION (2002)
Angiogenesis and plasticity: Role of erythropoietin in vascular systems
ZZ Chong et al.
JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH (2002)
Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice
M Pende et al.
NATURE (2000)