Journal
CANCER MEDICINE
Volume 9, Issue 7, Pages 2514-2523Publisher
WILEY
DOI: 10.1002/cam4.2850
Keywords
colon cancer; invasion; LINC00961; migration; miR-223-3p; SOX11
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Funding
- Characteristic Special project of Shanghai Minhang Commission of Health and Family Planning [2017MWTZ17]
- Shanghai municipal Health and Family Planning health Commission [201840036]
- JianFeng project of Shanghai Xuhui Commission of Health and Family Planning [SHXH201703]
- Shanghai Minhang Science and Technology Commission [2018MHZ102]
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Long noncoding RNAs play essential roles in colon cancer tumorigenesis. This study aimed to explore the potential function and molecular mechanisms of LINC00961 in colon cancer. qPCR results showed that LINC00961 was downregulated in colon cancer cells and tissues. Functional assays demonstrated that LINC00961 suppressed the migration and invasion of colon cancer cells in vitro. LINC00961 functioned as an endogenous sponge for miR-223-3p in colon cancer cells. SOX11 was confirmed as a target gene of miR-223-3p. The effect of miR-223-3p on colon cancer cells was then investigated. MiR-223-3p inhibition enhanced their migration and invasion. The effect of SOX11 on colon cancer cells was studied. SOX11 overexpression inhibited the invasion of colon cancer cells. LINC00961 acted as an anti-oncogene and upregulated SOX11 expression by functioning as a miR-223-3p sponge. This research revealed the molecular mechanism of LINC00961 in colon cancer. LINC00961 might act as a potential diagnostic biomarker and therapeutic target for further clinical treatments.
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