Journal
STEM CELLS INTERNATIONAL
Volume 2019, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2019/7135974
Keywords
-
Categories
Funding
- National Key Research and Development Program of China Stem Cell and Translational Research Key Projects [2018YFA0108301]
- Industry-University-Research Medical Project [12DZ1940405]
- National Natural Science Foundation of China [31971109, 81772075, 81701923]
- Shanghai Health System Excellent Personnel Training Plan [2017YQ028, 2018YQ38]
- Shanghai Science and Technology Commission Youth Science and technology star [17QA1405400]
Ask authors/readers for more resources
Seawater (SW) immersion can increase the damage of skin wounds and produce refractory wounds. However, few studies have been conducted to investigate the mechanisms of SW immersion on skin wounds. In our current study, we investigated the effect of human adipose-derived stem cells (hADSCs) on the repair of SW-treated full-thickness skin wounds and the underlying mechanisms. The results showed that SW immersion could reduce the expression of EGF and suppress the activation of the MEK/ERK signaling pathway. At the same time, the proliferation and migration of skin stem cells were inhibited by SW immersion, resulting in delayed wound healing. However, hADSCs significantly accelerated the healing of SW-immersed skin wounds by promoting cell proliferation and migration through the aforementioned mechanisms. Our results indicate a role for hADSCs in the repair of seawater-immersed skin wounds and suggest a potential novel treatment strategy for seawater-immersed wound healing.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available