Journal
MICROMACHINES
Volume 11, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/mi11020174
Keywords
microstereolithography; 3D printing; additive manufacturing; photo-curable polymer; micromanipulation; microtweezers; compliant mechanism
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Funding
- JST CREST [JPMJCR1905]
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In this study, a three-dimensional (3D) micromanipulator mounted on a glass capillary is developed for handling biological samples, such as multicellular spheroids and embryos. To fabricate the micromanipulator, we developed an additive manufacturing system based on high-resolution microstereolithography using a 405-nm blue laser. The fabrication system makes it possible to fabricate 3D microstructures on a glass capillary with 2.5 mu m lateral resolution and 25 mu m layer thickness. We also demonstrated the capture and release of a spheroid with the micromanipulator fabricated using our additive manufacturing system. We showed that spheroids can be easily handled by a simple operation with minimal damage using a cage-like multiple finger structure. Additive manufacturing of tailor-made micromanipulators mounted on a glass capillary will be useful in biological and tissue engineering research.
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