Journal
MICROMACHINES
Volume 11, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/mi11020158
Keywords
chronic wounds; angiogenesis; antibacterial properties; drug delivery; microfluidics; nanoparticles; microparticles
Categories
Funding
- National Institutes of Health [1R56DE029157, R01HL117213]
- Czech Academy of Sciences [MSM200111802]
- National Sustainability Program II (BIOCEV-FAR project) [LQ1604]
Ask authors/readers for more resources
Here, we developed a combinatorial delivery platform for chronic wound healing applications. A microfluidic system was utilized to form a series of biopolymer-based microparticles with enhanced affinity to encapsulate and deliver vascular endothelial growth factor (VEGF). Presence of heparin into the structure can significantly increase the encapsulation efficiency up to 95% and lower the release rate of encapsulated VEGF. Our in vitro results demonstrated that sustained release of VEGF from microparticles can promote capillary network formation and sprouting of endothelial cells in 2D and 3D microenvironments. These engineered microparticles can also encapsulate antibiotic-loaded nanoparticles to offer a dual delivery system able to fight bacterial infection while promoting angiogenesis. We believe this highly tunable drug delivery platform can be used alone or in combination with other wound care products to improve the wound healing process and promote tissue regeneration.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available