Journal
JOURNAL OF NANOBIOTECHNOLOGY
Volume 18, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12951-020-0580-1
Keywords
Iron oxide nanoparticles; SPION; MRI; MPI; Hyperthermia
Funding
- European Research Council (ERC) [309495, 680882, 813086]
- German Research Foundation (DFG) [GRK2375, 331065168, SFB/TRR57, SFB1066]
- RWTH Aachen University (ERS Prep Fund) [PFLS009]
- European Research Council (ERC) [680882, 813086] Funding Source: European Research Council (ERC)
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Superparamagnetic iron oxide nanoparticles (SPION) are extensively used for magnetic resonance imaging (MRI) and magnetic particle imaging (MPI), as well as for magnetic fluid hyperthermia (MFH). We here describe a sequential centrifugation protocol to obtain SPION with well-defined sizes from a polydisperse SPION starting formulation, synthesized using the routinely employed co-precipitation technique. Transmission electron microscopy, dynamic light scattering and nanoparticle tracking analyses show that the SPION fractions obtained upon size-isolation are well-defined and almost monodisperse. MRI, MPI and MFH analyses demonstrate improved imaging and hyperthermia performance for size-isolated SPION as compared to the polydisperse starting mixture, as well as to commercial and clinically used iron oxide nanoparticle formulations, such as Resovist (R) and Sinerem (R). The size-isolation protocol presented here may help to identify SPION with optimal properties for diagnostic, therapeutic and theranostic applications.
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