Journal
ELIFE
Volume 9, Issue -, Pages -Publisher
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.51507
Keywords
-
Categories
Funding
- National Institutes of Health [R01 AG04563, R01 AG10175, R01 AG028555]
- MacArthur Foundation
- Swedish Research Council for Health, Working Life and Welfare [97:0147:1B, 2009-0795, 2013-2292]
- Swedish Research Council [825-2007-7460, 2015-03255, 2017-00641, 2018-02077, 825-2009-6141, 521-2013-8689, 2019-01272]
- Karolinska Institutet Foundation for Geriatric Diseases
- Magnus Bergvall Foundation
- Karolinska Institutet
- King Gustaf V and Queen Victoria's Foundation of Freemasons
- China Scholarship Council
Ask authors/readers for more resources
Biological age measurements (BAs) assess aging-related physiological change and predict health risks among individuals of the same chronological age (CA). Multiple BAs have been proposed and are well studied individually but not jointly. We included 845 individuals and 3973 repeated measurements from a Swedish population-based cohort and examined longitudinal trajectories, correlations, and mortality associations of nine BAs across 20 years follow-up. We found the longitudinal growth of functional BAs accelerated around age 70; average levels of BA curves differed by sex across the age span (50-90 years). All BAs were correlated to varying degrees; correlations were mostly explained by CA. Individually, all BAs except for telomere length were associated with mortality risk independently of CA. The largest effects were seen for methylation age estimators (GrimAge) and the frailty index (FI). In joint models, two methylation age estimators (Horvath and GrimAge) and FI remained predictive, suggesting they are complementary in predicting mortality.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available