Journal
BIOTECHNIC & HISTOCHEMISTRY
Volume 90, Issue 7, Pages 552-558Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/10520295.2015.1016115
Keywords
oral lichen planus; oxidative stress; saliva
Categories
Funding
- Sectorial Operational Programme Human Programme Human Resources Development (SOP HRD) - European Social Fund
- Romanian Government [POSDRU/6/1.5/S/S17]
Ask authors/readers for more resources
There are few reports concerning the potential for clinical application of oxidative stress (OS) and collagen degradation markers in oral lichen planus (OLP) patients. We investigated the possibility of using some disease-related biomarkers in saliva and serum of OLP patients. Our study included 30 patients with OLP and 30 controls. We evaluated serum and salivary OS biomarkers including 8-OHdG, MDA, uric acid, TAC and GPx. We also investigated collagen degradation markers such as CTX I and MMP-8. We found significantly increased salivary levels of MMP-8 and CTX I in the OLP group compared to controls and significant differences between the OLP and control groups in serum and saliva for 8-OHdG, MDA (significantly increased), uric acid, TAC and GPx (significantly reduced). Currently there are no criteria for evaluating which OLP patients have a greater risk of malignant transformation. In addition to clinical surveillance, the serum and salivary biomarkers that we evaluated may be useful biomarkers for monitoring OLP patients in the future.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available