Journal
CLINICAL EPIGENETICS
Volume 12, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s13148-020-00826-4
Keywords
Histone methylation; Histone methyltransferase; Demethylase; Atherosclerosis; Intimal hyperplasia; Aortic dissection; aneurysm; Pulmonary arterial hypertension; Diabetic angiopathy; Cancer angiogenesis
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Funding
- National Natural Science Foundation of China [81600188, 81670050, 81873456]
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The vasculature not only transports oxygenated blood, metabolites, and waste products but also serves as a conduit for hormonal communication between distant tissues. Therefore, it is important to maintain homeostasis within the vasculature. Recent studies have greatly expanded our understanding of the regulation of vasculature development and vascular-related diseases at the epigenetic level, including by protein posttranslational modifications, DNA methylation, and noncoding RNAs. Integrating epigenetic mechanisms into the pathophysiologic conceptualization of complex and multifactorial vascular-related diseases may provide promising therapeutic approaches. Several reviews have presented detailed discussions of epigenetic mechanisms not including histone methylation in vascular biology. In this review, we primarily discuss histone methylation in vascular development and maturity, and in vascular diseases.
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