Journal
BMC GERIATRICS
Volume 20, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12877-020-1478-3
Keywords
Cognitive impairment; Dementia; Diagnostics; Prognostics; Neuropsychology; Biological markers
Categories
Funding
- Swedish Research Council (VR)
- Swedish Research Council for Health, Working Life and Welfare (FORTE)
- Swedish Foundation for Strategic Research (SSF)
- Strategic Research Programme in Neuroscience at Karolinska Institutet (StratNeuro)
- Ake Wiberg foundation
- Hjarnfonden
- Alzheimerfonden
- Demensfonden
- Stiftelsen Olle Engkvist Byggmastare
- Karolinska Institute
- Birgitta och Sten Westerberg
Ask authors/readers for more resources
Background There remains a lack of large-scale clinical studies of cognitive impairment that aim to increase diagnostic and prognostic accuracy as well as validate previous research findings. The MemClin project will amass large quantities of cross-disciplinary data allowing for the construction of robust models to improve diagnostic accuracy, expand our knowledge on differential diagnostics, strengthen longitudinal prognosis, and harmonise examination protocols across centres. The current article describes the Memory Clinic (MemClin) project's study-design, materials and methods, and patient characteristics. In addition, we present preliminary descriptive data from the ongoing data collection. Methods Nine out of ten memory clinics in the greater Stockholm area, which largely use the same examination methods, are included. The data collection of patients with different stages of cognitive impairment and dementia is coordinated centrally allowing for efficient and secure large-scale database construction. The MemClin project rest directly on the memory clinics examinations with cognitive measures, health parameters, and biomarkers. Results Currently, the MemClin project has informed consent from 1543 patients. Herein, we present preliminary data from 835 patients with confirmed cognitive diagnosis and neuropsychological test data available. Of those, 239 had dementia, 487 mild cognitive impairment (MCI), and 104 subjective cognitive impairment (SCI). In addition, we present descriptive data on visual ratings of brain atrophy and cerebrospinal fluid markers. Conclusions Based on our current progress and preliminary data, the MemClin project has a high potential to provide a large-scale database of 1200-1500 new patients annually. This coordinated data collection will allow for the construction of improved diagnostic and prognostic models for neurodegenerative disorders and other cognitive conditions in their naturalistic setting.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available