Fabrication of Platinum-Rhenium Nanoparticle-Decorated Porous Carbons: Voltammetric Sensing of Furazolidone

This study discusses the prospect of using biomass waste material, such as Cassia fistula (golden shower) fruit, as a carbon precursor in the development of new carbon material for the sustainable electrochemical sensor application. We successfully synthesized platinum-rhenium nanoparticles decorated on a porous activated carbon (Pt-Re NP/PAC) nanocomposite through the incorporation of metal precursors such as platinum(II) acetylacetonate (Pt(acac)(2)) and dirhenium decacarbonyl (Re-2(CO)(10)) via a facile thermal reduction process. A variety of physicochemical and electrochemical methods were employed to characterize the morphology, structural, and electrochemical properties of the Pt-Re NP/PAC material. We then looked into the analytical behavior and applications of GCE modified with Pt-Re NP/PAC (Pt-Re NP/PAC/GCE) for the determination of furazolidone (chemotherapy drug) by employing different voltammetric techniques. The influence of experimental conditions such as scan rate, pH, accumulation time, amount of the modifier, and sample concentration on the peak current of the furazolidone was studied. The proposed drug sensor exhibited a wide linear range (WLR) for furazolidone in 0.05 M phosphate-buffered saline (PBS, pH 7.0) from 1.0 to 299 mu M with a limit of detection (LOD) of 75.5 nM and appreciable sensitivity (5.52 mu A mu M-1 cm(-2)) which were calculated from linear sweep voltammetry (LSV). In addition, these analytical parameters including WLR, sensitivity, and LOD were estimated to be 0.2-117.7 mu M, 19.20 mu A mu M-1 cm(-2), and 20.8 nM and were obtained using differential pulse voltammetry (DPV). Therefore, the prepared Pt-Re NP/PAC modified sensor could be a potential candidate for the determination of furazolidone in pharmaceutical formulation, human urine, and blood serum samples, and the results are appreciable.