Journal
STEM CELLS TRANSLATIONAL MEDICINE
Volume 9, Issue 4, Pages 427-432Publisher
WILEY
DOI: 10.1002/sctm.19-0185
Keywords
immunoregulation; immunosuppression withdrawal; kidney transplantation; mesenchymal stromal cells; tolerance
Categories
Funding
- Fondazione ART per la ricerca sui Trapianti
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Here we report the case of successful immune tolerance induction in a living-donor kidney transplant recipient remotely treated with autologous bone marrow (BM)-derived mesenchymal stromal cells (MSC). This case report, which to the best of our knowledge is the first in the world in this setting, provides evidence that the modulation of the host immune system with MSC can enable the safe withdrawal of maintenance immunosuppressive drugs while preserving optimal long-term kidney allograft function.
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