Journal
POLYMERS
Volume 12, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/polym12030517
Keywords
polyelectrolyte; sulfated polymers; alpha-synuclein; amyloid aggregation; protein aggregation; artificial chaperone
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Funding
- Russian Science Foundation [16-14-10027]
- Moscow State University Development Program [PNR 5.13]
- Russian Science Foundation [19-14-13009] Funding Source: Russian Science Foundation
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The effect of a range of synthetic charged polymers on alpha-synuclein aggregation and amyloid formation was tested. Sulfated aromatic polymers, poly(styrene sulfonate) and poly(anethole sulfonate), have been found to suppress the fibril formation. In this case, small soluble complexes, which do not bind with thioflavin T, have been formed in contrast to the large stick-type fibrils of free alpha-synuclein. Sulfated polysaccharide (dextran sulfate), as well as sulfated vinylic polymer (poly(vinyl sulfate)) and polycarboxylate (poly(methacrylic acid)), enhanced amyloid aggregation. Conversely, pyridinium polycation, poly(N-ethylvinylpyridinium), switched the mechanism of alpha-synuclein aggregation from amyloidogenic to amorphous, which resulted in the formation of large amorphous aggregates that do not bind with thioflavin T. The obtained results are relevant as a model of charged macromolecules influence on amyloidosis development in humans. In addition, these results may be helpful in searching for new approaches for synucleinopathies treatment with the use of natural polymers.
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