Journal
POLYMERS
Volume 12, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/polym12020380
Keywords
chitosan; cholesterol; micelles; mPEG; redox-responsive
Categories
Funding
- National Natural Science Foundation of China [51403057]
- Natural Science Foundation of Heilongjiang Province [E2018052]
- Research and Development Project of Scientific and Technological Achievements for Colleges and Universities of Heilongjiang Province [TSTAU-R2018023]
- Fundamental Research for Colleges and Universities of Heilongjiang Province [2018-KYYWF-1559]
- Harbin Science and Technology Innovation Talents Special Fund Project [2016RQQXJ097]
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In this study, a redox-sensitive chitosan derivative with modifications by cholesterol, sulfhydryl, and mPEG (mPEG-CS(SH)-CHO) was successfully synthesized and characterized. Due to its amphiphilicity, the conjugate could spontaneously form micelles in an aqueous environment. The optimized paclitaxel (PTX)-loaded mPEG-CS(SH)-CHO micelles, with a mean diameter of 158 nm, zeta potential of +26.9 mV, drug loading of 11.7%, and entrapment efficiency of 88.3%, were successfully prepared. The results of an XRD study demonstrated that PTX was loaded in the core of the micelles in a non-crystalline state. Inspiringly, the PTX-loaded micelles possessed excellent anticancer effect but low toxicity to the body. It can be concluded that the mPEG-CS(SH)-CHO micellar system is a promising drug delivery carrier for the controlled release of PTX.
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