Journal
JOURNAL OF FLOW CHEMISTRY
Volume 10, Issue 1, Pages 199-206Publisher
SPRINGER
DOI: 10.1007/s41981-020-00086-6
Keywords
Continuous flow; Self-optimisation; Automation; Liquid-liquid extraction; Algorithm; Amines
Categories
Funding
- EPSRC [EP/N509681/1, EP/S513829/1]
- AstraZeneca
- University of Leeds
- EPSRC [1803783, EP/R032807/1] Funding Source: UKRI
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Downstream purification of products and intermediates is essential for the development of continuous flow processes. Described herein, is a study on the use of a modular and reconfigurable continuous flow platform for the self-optimisation of reactive extractions and multi-step reaction-extraction processes. The selective extraction of one amine from a mixture of two similar amines was achieved with an optimum separation of 90%, and in this case, the black-box optimisation approach was superior to global polynomial modelling. Furthermore, this methodology was utilised to simultaneously optimise the continuous flow synthesis and work-up of N-benzyl-alpha-methylbenzylamine with respect to four variables, resulting in a significantly improved purity.
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