Journal
CELL REPORTS
Volume 30, Issue 4, Pages 949-+Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2019.12.089
Keywords
-
Categories
Funding
- Fondation de France [171352]
- Fondation pour la Recherche Me dicale [SPF201809007124]
- Region Midi-Pyrenees (contrat de projets etat-region)
- Grand Toulouse community
- Association pour la Recherche sur le Cancer [8505]
- CNRS
- European Union through the Fonds Europeen de Developpement Regional program
Ask authors/readers for more resources
Under calorie restriction, bone marrow adipocytes (BM-Ads) do not decrease in size compared to white adipocytes, suggesting they harbor unique metabolic properties. We compare human primary BM-Ads with paired subcutaneous adipocytes (SC-Ads) using proteomic and lipidomic approaches. We find that, although SC-Ads and BM-Ads share similar morphological features, they possess distinct lipid metabolism. Although BM-Ad shows enrichment in proteins involved in cholesterol metabolism, correlating with increased free cholesterol content, proteins involved in lipolysis were downregulated. In particular, monoacylglycerol lipase expression is strongly reduced in BM-Ads, leading to monoacylglycerol accumulation. Consequently, basal and induced lipolytic responses are absent in BM-Ads, affirming their differences in metabolic fitness upon caloric restriction. These specific metabolic features are not recapitulated in vitro using common protocols to differentiate bone marrow mesenchymal stem cells. Thus, contrary to classical SC-Ads, BMAds display a specific lipid metabolism, as they are devoid of lipolytic activity and exhibit a cholesterol-orientated metabolism.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available