Journal
CELL REPORTS
Volume 30, Issue 4, Pages 1178-+Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2019.12.095
Keywords
-
Categories
Funding
- Knut and Alice Wallenberg Foundation [KAW 2014.0051]
- European Research Council [ERC 282012]
- Swedish Brain Foundation [Hjarnfonden FO2018-0107]
- Swedish Medical Research Council [VR-M 2015-02403]
- Karolinska Institutet Strategic Program for Neuroscience (StratNeuro)
- Karolinska Institutet
Ask authors/readers for more resources
To understand striatal function, it is essential to know the functional organization of the numerous inputs targeting the diverse population of striatal neurons. Using optogenetics, we activated terminals from ipsi- or contralateral primary somatosensory cortex (S1) or primary motor cortex (M1), or thalamus while obtaining simultaneous whole-cell recordings from pairs or triplets of striatal medium spiny neurons (MSNs) and adjacent interneurons. Ipsilateral corticostriatal projections provided stronger excitation to fast-spiking interneurons (FSIs) than to MSNs and only sparse and weak excitation to low threshold-spiking interneurons (LTSIs) and cholinergic interneurons (ChINs). Projections from contralateral M1 evoked the strongest responses in LTSIs but none in ChINs, whereas thalamus provided the strongest excitation to ChINs but none to LTSIs. In addition, inputs varied in their glutamate receptor composition and their short-term plasticity. Our data revealed a highly selective organization of excitatory striatal afferents, which is determined by both pre- and postsynaptic neuronal identity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available