Journal
CELL REPORTS
Volume 29, Issue 11, Pages 3460-+Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2019.11.029
Keywords
-
Categories
Funding
- Deutsche Forschungsgemeinschaft [LE 2420/2-1, SFB-TRR167/B3]
- Alexander von Humboldt Award
- Berliner Krebsgesellschaft e.V.
- Monika Kutzner Foundation
- BIH-Charite Clinician Scientist Program
- Medical Neuroscience graduate program of Charite, Berlin
- NeuroCure [Exc 257]
- Berlin Institute of Health/Einstein Fellowship grant
Ask authors/readers for more resources
Microglia express Toll-like receptors (TLRs) that sense pathogen- and host-derived factors, including single-stranded RNA. In the brain, let-7 microRNA (miRNA) family members are abundantly expressed, and some have recently been shown to serve as TLR7 ligands. We investigated whether let-7 miRNA family members differentially control microglia biology in health and disease. We found that a subset of let-7 miRNA family members function as signaling molecules to induce microglial release of inflammatory cytokines, modulate antigen presentation, and attenuate cell migration in a TLR7-dependent manner. The capability of the let-7 miRNAs to control microglial function is sequence specific, mapping to a let-7 UUGU motif. In human and murine glioblastoma/glioma, let-7 miRNAs are differentially expressed and reduce murine GL261 glioma growth in the same sequence-specific fashion through microglial TLR7. Taken together, these data establish let-7 miRNAs as key TLR7 signaling activators that serve to regulate the diverse functions of microglia in health and glioma.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available