Journal
ADVANCED HEALTHCARE MATERIALS
Volume 9, Issue 7, Pages -Publisher
WILEY
DOI: 10.1002/adhm.201901697
Keywords
drug delivery; fixation; magnetic manipulation; microrobots; targeted drug delivery
Funding
- Global Research Laboratory from the National Research Foundation of Korea (NRF)
- DGIST R&D Program - Ministry of Science and ICT [NRF 2017K1A1A2013237, 19-CoE-BT-02]
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A needle-type microrobot (MR) for targeted drug delivery is developed to stably deliver drugs to a target microtissue (MT) for a given period time without the need for an external force after affixing. The MRs are fabricatedby 3D laser lithography and nickel (Ni)/titanium oxide (TiO2) layers are coated by physical vapor deposition. The translational velocity of the MR is 714 mu m s(-1) at 20 mT and affixed to the target MT under the control of a rotating magnetic field. The manipulability of the MR is shown by using both manual and automatic controls. Finally, drug release from the paclitaxel-loaded MR is characterized to determine the efficiency of targeted drug delivery. This study demonstrates the utility of the proposed needle-type MR for targeted drug delivery to MT with various flow rates in vitro physiological fluidic environments.
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