Journal
THORACIC CANCER
Volume 11, Issue 2, Pages 488-492Publisher
WILEY
DOI: 10.1111/1759-7714.13275
Keywords
Dermatologic toxicities; immune checkpoint inhibitor (ICI); immune-related adverse events (IrAEs)
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Funding
- CAMS Innovation Fund for Medical Sciences (CIFMS) [2016-I2M-1-002]
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Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment. The unique spectrum of immune-related adverse events (IrAEs) may occur during treatment. Dermatologic toxicities appear to be one of the most prevalent immunotherapy-related adverse events. The most common symptoms are maculopapular rash and pruritus. Serious dermatologic toxicities including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reactions with eosinophilia and systemic symptoms are rare. In this review, we summarize guidelines of management of immunotherapy-related toxicities, case reports, and proposed treatment recommendation.
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