Journal
STEM CELL RESEARCH & THERAPY
Volume 11, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s13287-019-1536-y
Keywords
Cell sheet; Cardiac tissue; Myocardial infarction; Heart failure; Cell therapy; Mesenchymal stem cells; Skeletal myoblasts; Pluripotent stem cells; Inflammation; Angiogenesis
Funding
- Peking University Third Hospital Clinical Incubation Foundation [Y73536-01, Y73536-02]
- Beijing Natural Science Foundation [Z190013]
- National Natural Science Foundation of China [81970205]
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Stem cell-derived sheet engineering has been developed as the next-generation treatment for myocardial infarction (MI) and offers attractive advantages in comparison with direct stem cell transplantation and scaffold tissue engineering. Furthermore, induced pluripotent stem cell-derived cell sheets have been indicated to possess higher potential for MI therapy than other stem cell-derived sheets because of their capacity to form vascularized networks for fabricating thickened human cardiac tissue and their long-term therapeutic effects after transplantation in MI. To date, stem cell sheet transplantation has exhibited a dramatic role in attenuating cardiac dysfunction and improving clinical manifestations of heart failure in MI. In this review, we retrospectively summarized the current applications and strategy of stem cell-derived cell sheet technology for heart tissue repair in MI.
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