Journal
STATISTICS IN BIOPHARMACEUTICAL RESEARCH
Volume 12, Issue 3, Pages 394-396Publisher
AMER STATISTICAL ASSOC
DOI: 10.1080/19466315.2019.1707110
Keywords
Gold standard noninferiority trial; Linear contrast; Multi-arm randomized trial; Pre-stratification factor
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Tang derived the exact power formulas for t tests and analysis of covariance (ANCOVA) in superiority, noninferiority (NI), and equivalence trials. The power calculation in equivalence trials can be simplified by using Owen's Q function, which is available in standard statistical software. We extend the exact power determination method for ANCOVA to unstratified and stratified multi-arm randomized trials. The method is applied to the design of multi-arm trials and gold standard NI trials. for this article are available online.
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