Journal
SCIENTIFIC REPORTS
Volume 9, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-019-56137-z
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Funding
- MEXT/JSPS KAKENHI [26114002, 15H05862, 16H02505, 16K07378]
- Nakajima Foundation
- Inoue Science Research Award
- Naito Foundation
- Takeda Science Foundation
- Japan Agency for Medical Research and Development (Project for Elucidating and Controlling Mechanisms of Aging and Longevity)
- Inamori Fundation
- Toray Science Foundation
- Senri Life Science Foundation
- JSPS Research Fellowships for Young Scientists
- JSPS Overseas Challenge Program for Young Researchers
- Grants-in-Aid for Scientific Research [16H02505, 16K07378, 15H05862, 26114002] Funding Source: KAKEN
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Multicellular organisms repair injured epithelium by evolutionarily conserved biological processes including activation of c-Jun N-terminal kinase (JNK) signaling. Here, we show in Drosophila imaginal epithelium that physical injury leads to the emergence of dying cells, which are extruded from the wounded tissue by JNK-induced Slit-Roundabout2 (Robo2) repulsive signaling. Reducing Slit-Robo2 signaling in the wounded tissue suppresses extrusion of dying cells and generates aberrant cells with highly upregulated growth factors Wingless (Wg) and Decapentaplegic (Dpp). The inappropriately elevated Wg and Dpp impairs wound repair, as halving one of these growth factor genes cancelled wound healing defects caused by Slit-Robo2 downregulation. Our data suggest that JNK-mediated Slit-Robo2 signaling contributes to epithelial wound repair by promoting extrusion of dying cells from the wounded tissue, which facilitates transient and appropriate induction of growth factors for proper wound healing.
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