Journal
NUTRIENTS
Volume 12, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/nu12020411
Keywords
atopic dermatitis; Centella asiatica ethanol extract; madecassoside; asiaticoside; anti-inflammation
Categories
Funding
- Food Functionality Evaluation program under the Ministry of Agriculture, Food, and Rural Affairs
- Korea Food Research Institute [G0190300-01]
Ask authors/readers for more resources
Atopic dermatitis (AD) is a chronic inflammatory skin disease caused mainly by immune dysregulation. This study explored the anti-inflammatory and immunomodulatory effects of the Centella asiatica ethanol extract (CA) on an AD-like dermal disorder. Treatment with CA inhibited the expression of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in a dose-dependent manner in inflammatory stimulated HaCaT cells by interferon-gamma (IFN-gamma) and TNF-alpha-triggered inflammation. Eight-week-old BALB/c mice treated with 2,4-dinitrochlorobenzene (DNCB) were used as a mouse model of AD. In AD induce model, we had two types treatment of CA; skin local administration (80 mu g/cm(2), AD+CA-80) and oral administration (200 mg/kg/d, AD+CA-200). Interestingly, the CA-treated groups exhibited considerably decreased mast cell infiltration in the ear tissue. In addition, the expression of IL-6 in mast cells, as well as the expression of various pathogenic cytokines, such as TNF-alpha, IL-4, IL-5, IL-6, IL-10, IL-17, iNOS, COX-2, and CXCL9, was reduced in both AD+CA-80 and AD+CA-200 groups. Collectively, our data demonstrate the pharmacological role and signaling mechanism of CA in the regulation of allergic inflammation of the skin, which supports our hypothesis that CA could potentially be developed as a therapeutic agent for AD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available