Journal
MATERIALS
Volume 12, Issue 24, Pages -Publisher
MDPI
DOI: 10.3390/ma12244096
Keywords
Bio-responsive; Nanoparticle; pH-responsive; Enzyme-responsive; Biomolecule-responsive; Magnetic Resonance Imaging; Diagnosis; Therapy; Mesoporous Silica Nanoparticles; Iron Oxide Nanoparticles
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The use of nanoparticulate systems as contrast agents for magnetic resonance imaging (MRI) is well-established and known to facilitate an enhanced image sensitivity within scans of a particular pathological region of interest. Such a capability can enable both a non-invasive diagnosis and the monitoring of disease progression/response to treatment. In this review, magnetic nanoparticles that exhibit a bio-responsive MR relaxivity are discussed, with pH-, enzyme-, biomolecular-, and protein-responsive systems considered. The ability of a contrast agent to respond to a biological stimulus provides not only enriched diagnostic capabilities over corresponding non-responsive analogues, but also an improved longitudinal monitoring of specific physiological conditions.
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