Journal
BEILSTEIN JOURNAL OF NANOTECHNOLOGY
Volume 11, Issue -, Pages 421-431Publisher
BEILSTEIN-INSTITUT
DOI: 10.3762/bjnano.11.33
Keywords
cytotoxicity; macrocyclic receptors; nanoparticles; pillar[5]arene; self-assembly; silver
Funding
- RFBR [18-03-00315, 18-33-20148]
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For the first time, stable pillar[5]arene/Ag+ nanoparticles, consisting of water-soluble pillar[5]arene containing gamma-sulfobetaine fragments and Ag+ ions without Ag-Ag bonds, were synthesized and characterized. The pillar[5]arene/Ag+ (ratio 1:10) nanoparticles obtained were cubic with a rib length of 100 nm and are less cytotoxic than Ag+ ions. The survival of the A549 model cells in the presence of pillar[5]arene/Ag+ (1:10) nanoparticles at a concentration of 30 and 40 mu M was 76% and 55%, while in the absence of pillar[5]arene, the cell survival for free Ag+ ions at the same concentration was 30% and 10%, respectively. The results can be used to create new antibacterial materials and 2D biomedical coatings.
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