Journal
ACS CATALYSIS
Volume 10, Issue 2, Pages 955-993Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.9b04480
Keywords
catalytic enantioselective alpha-arylation; carbonyl enolates; alpha-halocarbonyl compounds; arylating agents
Categories
Funding
- National Key Research and Development Program of China [2018YFC1708100]
- National Natural Science Foundation of China [21901074, 81660576]
- projects of Guizhou province (Qian Ke He Zi ) [[2015]4032, [2019]1402, [2018]5766-10]
- Ministry of Education (PCSIRT)
- Fundamental Research Funds for the Central Universities
- Zijiang Scholar Program of East China Normal University
Ask authors/readers for more resources
Optically active alpha-arylation carbonyl units are widely present in a wide variety of drugs, bioactive natural products, and valuable pharmacologically active molecules. Catalytic enantioselective alpha-arylation of carbonyl enolates or the related precursors with various arylating agents constitutes a powerful tactic for constructing such privileged scaffolds, which is of great interest and has gained considerable progress. This review summarizes the advances based on two major strategies with diverse arylating agents, discusses in detail the reaction mechanism, limitations, and advantages of each method and their applications, and expounds the synthetic opportunities still open for further exploration.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available