Journal
NATURE COMMUNICATIONS
Volume 11, Issue 1, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-020-14728-9
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Funding
- National Institutes of Health grants [1R35GM128641, 1R01GM127710, 1R01GM130142]
- Van Andel Research Institute [XDB08020303]
- Biomedical Research Council of A*STAR including the Industry Alignment Fund Pre-Positioning [H18/01/a0/C14]
- UCAS joint Ph.D. Training Program
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Formylpeptide receptors (FPRs) as G protein-coupled receptors (GPCRs) can recognize formylpeptides derived from pathogens or host cells to function in host defense and cell clearance. In addition, FPRs, especially FPR2, can also recognize other ligands with a large chemical diversity generated at different stages of inflammation to either promote or resolve inflammation in order to maintain a balanced inflammatory response. The mechanism underlying promiscuous ligand recognition and activation of FPRs is not clear. Here we report a cryo-EM structure of FPR2-G(i) signaling complex with a peptide agonist. The structure reveals a widely open extracellular region with an amphiphilic environment for ligand binding. Together with computational docking and simulation, the structure suggests a molecular basis for the recognition of formylpeptides and a potential mechanism of receptor activation, and reveals conserved and divergent features in G(i) coupling. Our results provide a basis for understanding the molecular mechanism of the functional promiscuity of FPRs.
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