Journal
NATURE COMMUNICATIONS
Volume 11, Issue 1, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-020-14585-6
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Funding
- European Research Council (ERC) [3222809]
- Swiss National Science Foundation [310030B_147090, 310030B_185372, 31003A-166652]
- Human Frontier Science Program (HFSP) Long-Term Postdoctoral Fellowship [LT000779/2013]
- University of Basel
- Swiss National Science Foundation (SNF) [310030B_147090, 310030B_185372, 31003A_166652] Funding Source: Swiss National Science Foundation (SNF)
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Bacteria adapt their growth rate to their metabolic status and environmental conditions by modulating the length of their G1 period. Here we demonstrate that a gradual increase in the concentration of the second messenger c-di-GMP determines precise gene expression during G1/S transition in Caulobacter crescentus. We show that c-di-GMP stimulates the kinase ShkA by binding to its central pseudo-receiver domain, activates the TacA transcription factor, and initiates a G1/S-specific transcription program leading to cell morphogenesis and S-phase entry. Activation of the ShkA-dependent genetic program causes c-di-GMP to reach peak levels, which triggers S-phase entry and promotes proteolysis of ShkA and TacA. Thus, a gradual increase of c-di-GMP results in precise control of ShkA-TacA activity, enabling G1/S-specific gene expression that coordinates cell cycle and morphogenesis.
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