Journal
NATURE COMMUNICATIONS
Volume 11, Issue 1, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-020-14334-9
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Funding
- Australian National Health and Medical Research Council (NHMRC) [237117, 491209, 1066555, 628371, 1081288, 1085754, 1141354, 1127984, 1012236]
- Program for Interdisciplinary Neuroscience Traveling Fellowship from the Brigham and Women's Hospital
- US National Institutes of Health [HD058056]
- United Cerebral Palsy Foundation (USA)
- Leila Y. Mathers Charitable Foundation (USA)
- Brown Foundation (USA)
- Murdoch Children's Research Institute
- Royal Children's Hospital
- Royal Children's Hospital Foundation
- Department of Paediatrics, The University of Melbourne
- Victorian Government's Operational Infrastructure Support Program
- Australian National Health and Medical Research Council (NHMRC) (Centre for Clinical Research Excellence) [546519]
- Australian National Health and Medical Research Council (NHMRC) (Centre for Research Excellence) [1060733]
- National Health and Medical Research Council of Australia [1066555] Funding Source: NHMRC
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Serial regional brain growth from the newborn period to adolescence has not been described. Here, we measured regional brain growth in 216 very preterm (VP) and 45 full-term (FT) children. Brain MRI was performed at term-equivalent age, 7 and 13 years in 82 regions. Brain volumes increased between term-equivalent and 7 years, with faster growth in the FT than VP group. Perinatal brain abnormality was associated with less increase in brain volume between term-equivalent and 7 years in the VP group. Between 7 and 13 years, volumes were relatively stable, with some subcortical and cortical regions increasing while others reduced. Notably, VP infants continued to lag, with overall brain size generally less than that of FT peers at 13 years. Parieto-frontal growth, mainly between 7 and 13 years in FT children, was associated with higher intelligence at 13 years. This study improves understanding of typical and atypical regional brain growth. In this longitudinal study, the authors tracked the course of brain development from birth to adolescence (age 13 years) and examined the effects of very preterm birth. Very preterm children showed slower brain growth from age 0 (term equivalent) to age 7.
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