4.8 Article

Expanding the genome-targeting scope and the site selectivity of high-precision base editors

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Genome Engineering in Rice Using Cas9 Variants that Recognize NG PAM Sequences

Kai Hua et al.

MOLECULAR PLANT (2019)

Article Biochemistry & Molecular Biology

Improving Plant Genome Editing with High-Fidelity xCas9 and Non-canonical PAM-Targeting Cas9-NG

Zhaohui Zhong et al.

MOLECULAR PLANT (2019)

Article Multidisciplinary Sciences

Engineering of high-precision base editors for site-specific single nucleotide replacement

Junjie Tan et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors

Julian Grunewald et al.

NATURE (2019)

Letter Biotechnology & Applied Microbiology

Engineered xCas9 and SpCas9-NG variants broaden PAM recognition sites to generate mutations in Arabidopsis plants

Zengxiang Ge et al.

PLANT BIOTECHNOLOGY JOURNAL (2019)

Article Multidisciplinary Sciences

Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis

Changyang Zhou et al.

NATURE (2019)

Article Biotechnology & Applied Microbiology

CRISPR DNA base editors with reduced RNA off-target and self-editing activities

Julian Grunewald et al.

NATURE BIOTECHNOLOGY (2019)

Letter Biotechnology & Applied Microbiology

xCas9 expands the scope of genome editing with reduced efficiency in rice

Junjie Wang et al.

PLANT BIOTECHNOLOGY JOURNAL (2019)

Article Biochemistry & Molecular Biology

Highly Efficient A.T to G.C Base Editing by Cas9n-Guided tRNA Adenosine Deaminase in Rice

Fang Yan et al.

MOLECULAR PLANT (2018)

Article Multidisciplinary Sciences

Evolved Cas9 variants with broad PAM compatibility and high DNA specificity

Johnny H. Hu et al.

NATURE (2018)

Article Biotechnology & Applied Microbiology

Efficient base editing in methylated regions with a human APOBEC3A-Cas9 fusion

Xiao Wang et al.

NATURE BIOTECHNOLOGY (2018)

Article Biotechnology & Applied Microbiology

An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities

Jason M. Gehrke et al.

NATURE BIOTECHNOLOGY (2018)

Article Multidisciplinary Sciences

Engineered CRISPR-Cas9 nuclease with expanded targeting space

Hiroshi Nishimasu et al.

SCIENCE (2018)

Article Biotechnology & Applied Microbiology

Efficient C-to-T base editing in plants using a fusion of nCas9 and human APOBEC3A

Yuan Zong et al.

NATURE BIOTECHNOLOGY (2018)

Review Genetics & Heredity

Base editing: precision chemistry on the genome and transcriptome of living cells

Holly A. Rees et al.

NATURE REVIEWS GENETICS (2018)

Letter Biochemistry & Molecular Biology

Precise Editing of a Target Base in the Rice Genome Using a Modified CRISPR/Cas9 System

Yuming Lu et al.

MOLECULAR PLANT (2017)

Article Multidisciplinary Sciences

Programmable base editing of A.T to G.C in genomic DNA without DNA cleavage

Nicole M. Gaudelli et al.

NATURE (2017)

Article Biotechnology & Applied Microbiology

Precise base editing in rice, wheat and maize with a Cas9-cytidine deaminase fusion

Yuan Zong et al.

NATURE BIOTECHNOLOGY (2017)

Article Biotechnology & Applied Microbiology

Targeted base editing in rice and tomato using a CRISPR-Cas9 cytidine deaminase fusion

Zenpei Shimatani et al.

NATURE BIOTECHNOLOGY (2017)

Article Biotechnology & Applied Microbiology

Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions

Y. Bill Kim et al.

NATURE BIOTECHNOLOGY (2017)

Article Cell Biology

Correction of β-thalassemia mutant by base editor in human embryos

Puping Liang et al.

PROTEIN & CELL (2017)

Review Biochemistry & Molecular Biology

CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes

Alexis C. Komor et al.

Article Biochemistry & Molecular Biology

ClinVar: public archive of interpretations of clinically relevant variants

Melissa J. Landrum et al.

NUCLEIC ACIDS RESEARCH (2016)

Article Multidisciplinary Sciences

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

Alexis C. Komor et al.

NATURE (2016)

Article Multidisciplinary Sciences

Teleseismic S wave microseisms

Kiwamu Nishida et al.

SCIENCE (2016)

Article Multidisciplinary Sciences

Engineered CRISPR-Cas9 nucleases with altered PAM specificities

Benjamin P. Kleinstiver et al.

NATURE (2015)

Review Biochemistry & Molecular Biology

Therapeutic genome editing: prospects and challenges

David Benjamin Turitz Cox et al.

NATURE MEDICINE (2015)

Review Microbiology

Unravelling the structural and mechanistic basis of CRISPR-Cas systems

John van der Oost et al.

NATURE REVIEWS MICROBIOLOGY (2014)

Article Biochemistry & Molecular Biology

Deciphering key features in protein structures with the new ENDscript server

Xavier Robert et al.

NUCLEIC ACIDS RESEARCH (2014)

Review Multidisciplinary Sciences

The new frontier of genome engineering with CRISPR-Cas9

Jennifer A. Doudna et al.

SCIENCE (2014)

Article Multidisciplinary Sciences

Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation

Martin Jinek et al.

SCIENCE (2014)

Letter Biotechnology & Applied Microbiology

Targeted mutagenesis in the model plant Nicotiana benthamiana using Cas9 RNA-guided endonuclease

Vladimir Nekrasov et al.

NATURE BIOTECHNOLOGY (2013)

Article Biotechnology & Applied Microbiology

RNA-guided editing of bacterial genomes using CRISPR-Cas systems

Wenyan Jiang et al.

NATURE BIOTECHNOLOGY (2013)

Article Multidisciplinary Sciences

RNA-Guided Human Genome Engineering via Cas9

Prashant Mali et al.

SCIENCE (2013)

Article Multidisciplinary Sciences

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

Martin Jinek et al.

SCIENCE (2012)

Article Biochemical Research Methods

Clustal W and clustal X version 2.0

M. A. Larkin et al.

BIOINFORMATICS (2007)

Article Multidisciplinary Sciences

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Aβ42 production

T Moehlmann et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)