Journal
NATURE COMMUNICATIONS
Volume 11, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41467-020-14391-0
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Funding
- National Institutes of Health [5R01-HG006137, 1U2CCA233285-01]
- National Science Foundation [DMS-1562665]
- Wharton Dean's Fund for Post-doctoral Research
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While single cell RNA sequencing (scRNA-seq) is invaluable for studying cell populations, cell-surface proteins are often integral markers of cellular function and serve as primary targets for therapeutic intervention. Here we propose a transfer learning framework, single cell Transcriptome to Protein prediction with deep neural network (cTP-net), to impute surface protein abundances from scRNA-seq data by learning from existing single-cell multi-omic resources. Cell-surface proteins serve as phenotypic cell markers and in many cases are more indicative of cellular function than the transcriptome. Here, the authors introduce a transfer learning framework to impute surface protein abundances from scRNA-seq data.
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