Journal
ONCOLOGY LETTERS
Volume 19, Issue 4, Pages 3059-3070Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2020.11437
Keywords
curcumin; tumor suppressive immune environment; immune response; cytotoxic T cells; natural killer cell; clinical trials
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Funding
- China Academy of Medical Sciences Innovation Fund for Medical Sciences [2016-I2M-3-019]
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Cancer is a harmful threat to human health. In addition to surgery, a variety of anticancer drugs are increasingly used in cancer therapy; however, despite the developments in multimodality treatment, the morbidity and mortality of patients with cancer patients are on the increase. The tumor-specific immunosuppressive microenvironment serves an important function in tumor tolerance and escape from immune surveillance leading to tumor progression. Therefore, identifying new drugs or foods that can enhance the tumor immune response is critical to develop improved cancer prevention methods and treatment. Curcumin, a polyphenolic compound extracted from ginger, has been shown to effectively inhibit tumor growth, proliferation, invasion, metastasis and angiogenesis in a variety of tumors. Recent studies have also indicated that curcumin can modulate the tumor immune response and remodel the tumor immunosuppressive microenvironment, indicating its potential in the immunotherapy of cancer. In this review, a brief introduction to the effects of curcumin on the tumor immune response and tumor immune microenvironment is provided and recent clinical trials investigating the potential of curcumin in cancer therapy are discussed.
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