Journal
EPIGENOMICS
Volume 12, Issue 2, Pages 101-125Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2019-0058
Keywords
breast cancer; ceRNA; circRNAs; exosomes; miRNA
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Funding
- National Key Research and Development Program of China [2016YFC0905900]
- National Natural Science Foundation of China [81602551, 81702613, 81872365]
- '333' Talent Project of Jiangsu Province [4[2016]]
- Innovation Team Construction Project of Nanjing Medical University [JX102GSP201727]
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Aim: Circular RNAs (circRNAs) still have many potential functions in the process of tumor development that are not completely understood. The study aims to explore novel circRNAs and their mechanisms of action in breast cancer (BCa). Materials & methods: A combination strategy of RNA-sequencing (RNA-seq) technique, quantitative real-time PCR and bioinformatic analysis was employed to identify the potential mechanisms involving differentially expressed circRNAs in the serum exosomes and tissues of BCa patients. Results: The expression levels of hsa-circRNA-0005795 and hsa-circRNA-0088088 were significantly different both in serum exosomes and tissues and might function as competing endogenous RNAs and play vital roles in BCa development. Conclusion: We constructed two circRNA-miRNA networks and provided new insight into the prognosis and therapy of BCa using circRNAs from serum exosomes.
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