Journal
ACS MEDICINAL CHEMISTRY LETTERS
Volume 11, Issue 3, Pages 228-231Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsmedchemlett.9b00582
Keywords
Chemical modalities; RNA; PROTAC; cyclopeptides; target validation; strategy
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The classical toolbox for drug discovery is continuously expanding beyond traditional small molecules. New chemical modalities including RNA therapeutics, protein degraders, cyclopeptides, antibody drug conjugates, and gene therapy have matured, demonstrating clinical success and are now considered early in target appraisal. In this Viewpoint, we highlight recent progress in the field.
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