Journal
WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE
Volume 12, Issue 3, Pages -Publisher
WILEY
DOI: 10.1002/wsbm.1474
Keywords
immunity; inflammation; lactate; metabolism; tumor
Categories
Funding
- TIMING Project
- Research Centre and Regione Campania CISI-Lab
- University of Birmingham Professorial Research Fellowship
- British Heart Foundation Intermediate Basic Science Research Fellowship [FS/12/38/29640]
- Versus Arthritis [21386]
- MRC [MR/T016736/1] Funding Source: UKRI
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It is becoming increasingly appreciated that intermediates of metabolic pathways, besides their anabolic and catabolic functions, can act as signaling molecules and influence the outcome of immune responses. Although lactate was previously considered as a waste product of glucose metabolism, accumulating evidence has highlighted its pivotal role in regulating diverse biological processes, including immune cell polarization, differentiation and effector functions. In addition, lactate is a key player in modulating tumor immune surveillance. Hence, targeting lactate-induced signaling pathways is a promising tool to reduce inflammation, to prevent autoimmunity and to restore anti-tumor immune response. This article is characterized under: Biological Mechanisms > Metabolism
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