Journal
SAUDI PHARMACEUTICAL JOURNAL
Volume 28, Issue 4, Pages 427-439Publisher
ELSEVIER
DOI: 10.1016/j.jsps.2020.02.003
Keywords
Traditional herbal formula; Hyeonggaeyeongyo-tang; Simultaneous determination; HPLC-PDA; LC-MS/MS
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Funding
- Korea Institute of Oriental Medicine [KSN1812240]
- National Research Council of Science & Technology (NST), Republic of Korea [KSN1812240] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Simultaneous analysis of 20 marker components (gallic acid, cimifugin, geniposide, paeoniflorin, ferulic acid, nodakenin, narirutin, naringin, neohesperidin, arctiin, baicalin, oxypeucedanin hydrate, wogonoside, baicalein, arctigenin, glycyrrhizin, wogonin, pulegone, decursin, and decursinol angelate) for quality assessment of the traditional herbal formula, Hyeonggaeyeongyo-tang (HYT) was carried out by using high-performance liquid chromatography (HPLC) with photodiode array detection (PDA) and liquid chromatography-mass spectrometry with tandem mass spectrometry (LC-MS/MS). The coefficient of determination showed excellent linearity of more than 0.9999 for all analytes. The recovery of 20 marker components was 93.92 to 102.66% with relative standard deviation (RSD) < 3.00% and RSD value of precision was <= 3.44%. The amounts of 20 marker components using HPLC-PDA and LC-MS/MS were determined to be 0.18-14.60 and 0.01-1.76 mg/freeze-dried g, respectively. (C) 2020 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.
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