Journal
BIOSENSORS & BIOELECTRONICS
Volume 64, Issue -, Pages 212-218Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2014.08.083
Keywords
Pyrrole-phenylboronic acid; Electrochemical sensor; Dopamine; Molecular imprinting polymer; Double recognition
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Funding
- National Natural Science Foundation of China for Young Program [21005002]
- Natural Science Foundation of Anhui Province for Young Program [11040606Q35]
- Anhui University Provincial Natural Science Foundation Key Program [KJ2010A138]
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A molecular imprinting polymer (MIP) based electrochemical sensor was successfully prepared for dopamine (DA) recognition and detection using pyrrole-phenylboronic acid (py-PBA) as a novel electropolymerized monomer. py-PBA could form cyclic boronic ester bond with DA, thus endowing a double recognition capacity of the sensor to DA in the combination of the imprinted effect of MIP. Compared with the sensor prepared using pyrrole or phenylboronic acid as electropolymerized monomer, the present sensor exhibited a remarkable high imprinted factor to DA. The influence factors including pH value, the mole ratio between monomer and template molecule, electropolymerization scan rate, and scan cycles of electropolymerization process were investigated and optimized. Under the optimal conditions, the sensor could recognize DA from its analogs and monosaccharides. A linear ranging from 5.0 x 10(-8) to 1.0 x 10(-5) mol/L for the detection of DA was obtained with a detection limit of 3.3 x 10(-8) mol/L (S/N=3). The sensor has been applied to analyze DA in injection samples with satisfactory results. (C) 2014 Elsevier B.V. All rights reserved.
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