Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 66, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jff.2020.103795
Keywords
Epigallocatechin-3-gallate; Cigarette smoke; Prostate; Epithelial-mesenchymal transition; Fibrosis; Hedgehog
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Funding
- State Natural Sciences Fund of China [81703594, 81603177]
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Cigarettes consumption is popular all over the world. In the meantime, green tea is widely accepted for their health benefits. Epigallocatechin-3-gallate (EGCG) is the most abundant catechin in green tea. This study aimed to investigate the effects of cigarette smoke (CS) exposure on human prostate cells and rat prostate, as well as the potential protective functions of EGCG. The results suggested that chronic CS exposure stimulated prostatic epithelial-mesenchymal transition (EMT), collagen deposition and fibrosis. Down-regulation of the Hedgehog (HH) signaling pathway helped to ameliorate CS-induced prostatic deficits. Meanwhile, EGCG could exhibit strong anti-fibrosis effects on prostate. Its underlying mechanisms were related to modulate EMT and decrease the activity of HH signal pathway.
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