Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 65, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jff.2020.103781
Keywords
Kaempferitrin; Obesity; Pro-inflamatory genes; Liver; High-fat diet; Inflammation
Categories
Funding
- CONACYTCB-2013-01 [220732-1010/532/2014]
- Mexican National Council for Science and Technology (CONACYT) [552610/295319]
- [SIP-2018048]
- [SIP-20195333]
Ask authors/readers for more resources
Justicia spicigera is a plant used in traditional Mexican medicine to treat various diseases such as heart diseases and to improve blood circulation, with little scientific evidence. Therefore, this study evaluated the effect of the leaves of the plant and of kaempferitrin (main active ingredient), on biochemical, physiological, and inflammation markers related to obesity induced by a high-fat diet in male Wistar rats for eight weeks. The results indicated that J. spicigera powder has the ability to significantly decrease (p <= 0.05) the percentage of accumulated fat, and consequently, weight gain, as well as serum triglyceride concentrations. In addition, both J. spicigera powder and kaempferitrin generated transcriptional adaptations by negatively modulating the expression of pro-inflammatory genes such as Tlr4, Tnf-alpha, Nlrp3, Caspase-1, Il-18, Il-1 beta, Srebp-1c, Ppar-gamma and Ucp2 and overexpressing Ppar-alpha.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available