Journal
VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE
Volume 50, Issue 2, Pages 431-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.cvsm.2019.11.004
Keywords
Dog; Interstitial lung disease; Idiopathic interstitial pneumonia; Arterial blood gas analysis; HRCT; Bronchoalveolar lavage; Biomarker
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Funding
- Orion-Farmos Research Foundation
- Finnish Veterinary Association
- Finnish Veterinary Research Foundation
- Finnish West Highland White Terrier Breeding Club
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Canine idiopathic pulmonary fibrosis (CIPF) is a chronic, progressive, interstitial lung disease (ILD) affecting older West Highland white terriers (WHWTs). According to one classification, CIPF is a familial fibrotic ILD in the group of idiopathic interstitial pneumonias. Etiology is unknown but likely arises from interplay between genetic and environmental factors. CIPF shares features with human idiopathic pulmonary fibrosis and human nonspecific interstitial pneumonia. This article describes clinical signs, findings in physical examination, arterial oxygenation, diagnostic imaging, bronchoscopy, bronchoalveolar lavage, histopathology, disease course, and outcome of WHWTs with CIPF; compares canine and human diseases; summarizes biomarker research; and gives an overview of potential treatment.
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