Crosstalk between transforming growth factor-beta signaling pathway and long non-coding RNAs in cancer

The transforming growth factor-beta (TGF-beta) signaling pathway plays an important role in tumorigenesis by exerting either a tumor-suppressing or tumor-promoting effect. Long non-coding RNAs (lncRNAs), a newly discovered class of non-coding RNAs, have been widely studied in recent years and identified as crucial regulators of various biological processes, including cell cycle progression, chromatin remodeling, gene transcription, and posttranscriptional processing. Recent evidence, addressing the crosstalk between the TGF-beta signaling pathway and lncRNAs in cancer, found that several members of the TGF-beta pathway are targeted by lncRNAs, and the production of hundreds of lncRNAs is induced by TGF-beta treatment. This review will summarize the latest progress on the investigation of TGF-beta pathway and lncRNA network in regulating cancer development. Further study on the network would provide a better understanding of carcinogenesis and have potentials for the prevention and treatment of malignant diseases. (C) 2015 Elsevier Ireland Ltd. All rights reserved.