Journal
CANCER LETTERS
Volume 382, Issue 1, Pages 118-126Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2016.01.041
Keywords
Molecular profiling; Precision medicine; Radiation oncology; Targeted therapy
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Funding
- NIH Intramural Research Program, National Cancer Institute, Center for Cancer Research
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New technologies enabling the analysis of various molecules, including DNA, RNA, proteins and small metabolites, can aid in understanding the complex molecular processes in cancer cells. In particular, for the use of novel targeted therapeutics, elucidation of the mechanisms leading to cell death or survival is crucial to eliminate tumor resistance and optimize therapeutic efficacy. While some techniques, such as genomic analysis for identifying specific gene mutations or epigenetic testing of promoter methylation, are already in clinical use, other omics-based assays are still evolving. Here, we provide an overview of the current status of molecular profiling methods, including promising research strategies, as well as possible challenges, and their emerging role in radiation oncology. Published by Elsevier Ireland Ltd.
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