Journal
TRENDS IN PLANT SCIENCE
Volume 24, Issue 12, Pages 1094-1101Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tplants.2019.09.012
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Funding
- Agence Nationale de la Recherche (ANR) Jeunes Chercheuses/Jeunes Chercheurs grant [ANR-12-JSV6-0004-01]
- Agence Nationale de la Recherche (ANR) [ANR-12-JSV6-0004] Funding Source: Agence Nationale de la Recherche (ANR)
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In animal cells, nuclear DNA is the target of genotoxins produced by bacterial pathogens that cause genomic mutations eventually leading to apoptosis, senescence, and carcinogenic development. In response to the insult, the DNA damage response (DDR) is activated to ensure lesion repair. Accumulation of DNA breaks is also detected in plants during microbial infection. In this opinion article we propose that phytopathogens can produce DNA-damaging effectors. The recent identification of a functional genotoxin in devastating eukaryotic plant pathogens, such as oomycetes, supports the concept that DNA-damaging effectors may contribute to pathogenicity. Additionally, this raises the question of how plants can perceive these damages and whether this perception can be connected to the plant immune system.
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