Journal
TRENDS IN PLANT SCIENCE
Volume 25, Issue 5, Pages 466-476Publisher
CELL PRESS
DOI: 10.1016/j.tplants.2020.01.001
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Funding
- National Key R&D Program of China [2018YFA0900600]
- Bill and Melinda Gates Foundation [OPP1199872]
- Young Scientists Fund of the National Natural Science Foundation of China [31600231]
- China National Transgenic Plant Research and Commercialization Project [2016ZX08002-001]
- Bill and Melinda Gates Foundation [OPP1199872] Funding Source: Bill and Melinda Gates Foundation
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Plants regulate the synthesis of specialized compounds through the actions of individual transcription factors (TFs) or sets of TFs. One such compound, artemisinin from Artemisia annua, is widely used as a pharmacological product in the first-line treatment of malaria. However, the emergence of resistance to artemisinin in Plasmodium species, as well as its low production rates, have required innovative treatments such as exploiting the synergistic effects of flavonoids with artemisinin. We overview current knowledge about flavonoid and artemisinin transcriptional regulation in A. annua, and review the dual action of TFs and structural genes that can regulate both pathways simultaneously. Understanding the concerted action of these TFs and their associated structural genes can guide the development of strategies to further improve flavonoid and artemisinin production.
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