Journal
TRENDS IN PARASITOLOGY
Volume 36, Issue 2, Pages 147-157Publisher
CELL PRESS
DOI: 10.1016/j.pt.2019.11.004
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Funding
- National Institutes of Health (NIH) [AI42767, AI085515, AI100527, AI114543]
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Each year over 200 million malaria infections occur, with over 400 000 associated deaths. Vaccines formed with attenuated whole parasites can induce protective memory CD8 T cell responses against liver-stage malaria; however, widespread administration of such vaccines is logistically chap lenging. Recent scientific findings are delineating how protective memory CD8 T cell populations are primed and maintained and how such cells mediate immunity to liver-stage malaria. Memory CD8 T cell anatomic localization and expression of transcription factors, homing receptors, and signaling molecules appear to play integral roles in protective immunity to fiver-stage malaria Further investigation of how such factors contribute to optimal protective memory CD8 T cell generation and maintenance in humans will inform efforts for improved vaccines.
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