Journal
TRENDS IN NEUROSCIENCES
Volume 43, Issue 3, Pages 144-154Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2020.01.003
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Funding
- NIMH [R01 MH119349]
- Pew Charitable Trusts
- Burroughs Wellcome Fund
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Healthy central nervous system (CNS) development and function require an intricate and balanced bidirectional communication between neurons and glia cells. In this review, we discuss the complementary roles of astrocytes and microglia in building the brain, including in the formation and refinement of synapses. We discuss recent evidence demonstrating how these interactions are coordinated in the transition from healthy physiology towards disease and discuss known and potential molecular mechanisms that mediate this cellular crosstalk.
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