Journal
TRENDS IN NEUROSCIENCES
Volume 43, Issue 3, Pages 130-132Publisher
CELL PRESS
DOI: 10.1016/j.tins.2020.01.001
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Funding
- European Research Council (ERC-2018-STG) [802041]
- INSERM ATIP-Avenir program
- NIH [R01NS054791]
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Recent studies revealed the existence of unique functional links between mast cells and nociceptors in the skin. Here, we propose that mast cells and nociceptors form a single regulatory unit in both physiology and disease. In this model, MrgprB2/X2 signaling is a primary mechanism by which mast cells functionally interact with nociceptors to form specialized neuroimmune clusters that regulate pain, inflammation, and itch.
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