Journal
TRENDS IN IMMUNOLOGY
Volume 40, Issue 12, Pages 1149-1162Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2019.10.006
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Funding
- Priority-Driven Collaborative Cancer Research Scheme
- Cancer Australia
- Cure Cancer Australia Foundation [1123388]
- Victorian Cancer Agency
- NIH [AI112579, AI121080, AI139874]
- Veteran Affairs BLRAMP
- D Merit Review Program [BX002903]
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T cell factor-1 (TCF-1), encoded by Tcf7, is a transcription factor and histone deacetylase (HDAC) essential for commitment to both the T cell and the innate lymphoid cell (ILC) lineages in mammals. In this review, we discuss the multifunctional role of TCF-1 in establishing these lineages and the requirement for TCF-1 throughout lineage differentiation and maintenance of lineage stability. We highlight recent reports showing promise for TCF-1 as a novel biomarker to identify recently characterized subsets of exhausted CD8(+) T cells that may help to predict patient responses to immune checkpoint blockade (ICB).
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